医药卫生—神经病学与精神病学

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相关作者:王拥军陈生弟贾建平孙圣刚肖波更多>>
相关机构:复旦大学中南大学首都医科大学宣武医院山东大学更多>>
发文主题:脑梗死精神分裂症脑卒中疗效观察急性脑梗死更多>>
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发文基金:国家自然科学基金国家重点基础研究发展计划国家科技支撑计划广东省自然科学基金更多>>
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Lithium beyond psychiatric indications:the reincarnation of a new old drug
《中国神经再生研究:英文版》2021年第12期2383-2387,共5页Matteo Haupt Mathias Bähr Thorsten R.Doeppner 
Lithium has been used in the treatment of bipolar disorders for decades,but the exact mechanisms of action remain elusive to this day.Recent evidence suggests that lithium is critically involved in a variety of signal...
关键词:Alzheimer’s disease apoptosis bench-to-bedside translation inflammation ischemic stroke LITHIUM NEUROGENESIS neuroprotective agent Parkinson’s disease traumatic brain injury 
Abnormal metal homeostasis as a common drug target to combat neurodegenerative diseases
《中国神经再生研究:英文版》2021年第12期2388-2389,共2页Dagmar Pretsch 
The author is a recipient of a DOC Fellowship of the Austrian Academy of Sciences(Dr.Ignaz Seipel-Platz 2,1010 Vienna)at the Department of Pharmacognosy,University of Vienna,Althanstrasse 14,A-1090 Vienna,Austria.
As life expectancy increases,the prevalence of age-related diseases will also increase.There has been an estimation that 50 million individuals are living with dementia in 2019.This number will increase to 75 million ...
关键词:DISEASES HUNTINGTON DEGENERATIVE 
Caspase-1:an important player and possible target for repair of the blood-brain barrier underlying neurodegeneration
《中国神经再生研究:英文版》2021年第12期2390-2392,共3页Daniel Rand Itzik Cooper 
This work was supported by the Defense Threat Reduction Agency-Joint Science&Technology Office for Chemical&Biological Defense(No.11816372);the Nehemia Rubin Excellence in Biomedical Research-The TELEM Program supported by the Aaron Gutwirth Fund and by Ministry of Science and Technology(No.3-13576).
Our ageing population is bearing an increasing burden on society with an unprecedented rise in brain disease,especially neurodegeneration.Treatment for neurodegeneration is practically nonexistent,one major reason bei...
关键词:NEURODEGENERATION BARRIER REMOVE 
Microglia activation:a role for mitochondrial DNA?
《中国神经再生研究:英文版》2021年第12期2393-2394,共2页Marcello Pinti Diana Ferraro Milena Nasi 
The present work was supported by the Italian Multiple Sclerosis Foundation(FISM)[grant“Mitochondrial DAMPs in Multiple Sclerosis:a pilot study”,code 2017/R/10](to MN and DF).
Microglial cells and perivascular macrophages are the only resident immune cells of the brain parenchyma and act as innate immune sentinels in the central nervous system(CNS).Microglial cells are vital for the mainten...
关键词:HOMEOSTASIS ACTIVATION STRICT 
Light of the stars:calcium signals light up astrocytes in the presence of autoreactive CD4+T cells
《中国神经再生研究:英文版》2021年第12期2395-2396,共2页Jelena BogdanovićPristov Ljiljana Nikolić 
The present work was supported by the Ministry of Education,Science and Technological Development of Republic of Serbia(Contract No.451-03-68/2020-14/200007(to LN),451-03-68/2020-14/200053)(to JBP),and a Fellowship Start up for Science from the Centre for Leadership Development(to LN).
Introduction:Astrocytes play important roles in the central nervous system(CNS)to support and regulate CNS function.They are abundant type of glia that form a meshwork of interconnected cells almost completely tiling ...
关键词:function. ASTROCYTES cytes 
A 3R-Tau-mediated mechanism in oligodendrocytes:could it be the key for neuroprotection after stroke?
《中国神经再生研究:英文版》2021年第12期2401-2402,共2页Mario Villa Gonzalez Maria JoséPérez-Álvarez 
This work was supported by grants from Spanish Ministry of Economy and Competitiveness(BFU-2008-03980,BFU2016-77885-P),from Comunidad de Madrid(S2017/BMD-3700)and from Departamento de Biología,Facultad de Ciencias-UAM(BIOUAM03-2020).
Anoverview of cerebral ischemia:Cerebrovascular accident or stroke have a high global incidence.The most common types of stroke are ischemic,accounting for 87%of the total number,and they are triggered by a reduction ...
关键词:cerebral ISCHEMIA damage 
Combinatorial genetics methods for discovering high-order regulatory combinations and engineering genetic drivers for neural differentiation
《中国神经再生研究:英文版》2021年第12期2403-2404,共2页Dawn G.L.Thean Alan S.L.Wong 
The present work was supported by the University of Hong Kong Internal funds,Croucher Foundation Start-up Allowance,and NSFC 2020 Excellent Young Scientists Fund(to ASLW).
Diving into the search for effective cell differentiation factors:Researchers are still striving to find better therapeutics to revert or slow down the progression of neurological disorders such as Parkinson’s diseas...
关键词:HUNTINGTON neural Alzheimer 
BACE1 role in Alzheimer’s disease and other dementias:from the theory to the practice
《中国神经再生研究:英文版》2021年第12期2407-2408,共2页Carlo Cervellati Giuseppe Valacchi Giovanni Zuliani 
Beta-site amyloid precursor protein(APP)cleaving enzyme-1(BACE1):brief overview on the biology and its role in Alzheimer’s disease(AD)pathogenesis:AD is a multifactorial and multifaceted disease,with a complex and st...
关键词:BACE1 ALZHEIMER al. 
Rogue gene networks gone awry in Alzheimer’s disease
《中国神经再生研究:英文版》2021年第12期2415-2416,共2页Emily Miyoshi Vivek Swarup 
The human brain consists of billions of cells encompassing hundreds of distinct cell-types,each with unique functions and properties.Identification of the molecular architecture of the brain has been revolutionized by...
关键词:ALZHEIMER properties. hundreds 
A long story for a short peptide:therapeutic efficacy of a cleavagespecific tau antibody
《中国神经再生研究:英文版》2021年第12期2417-2419,共3页Giuseppina Amadoro Valentina Latina Pietro Calissano 
The present work was supported by in part by Fondo Ordinario Enti(FOE D.M865/2019)in the framework of a collaboration agreement between the Italian National Research Council and EBRI(2019-2021)(to PC).VL was supported by Post-doctoral Fellowship by Operatori Sanitari Assistiti(OSA).
Tau is the prime participant in the Alzheimer’s disease(AD) neurodegeneration:AD,the main cause of dementia in elderly people,is a multifactorial neurodegenerative disorder characterized by a long prodromal phase(sta...
关键词:TAU  ALZHEIMER 
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