医药卫生

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相关作者:胡大一王伟李静李莉张伟更多>>
相关机构:复旦大学中国人民解放军总医院华中科技大学同济医学院山东大学更多>>
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Potential effects of mesenchymal stem cell derived extracellular vesicles and exosomal miRNAs in neurological disorders
《中国神经再生研究:英文版》2021年第12期2359-2366,共8页Masako Nakano Mineko Fujimiya 
Mesenchymal stem cells are multipotent cells that possess anti-inflammatory,antiapoptotic and immunomodulatory properties.The effects of existing drugs for neurodegenerative disorders such as Alzheimer’s disease are ...
关键词:EXOSOMES extracellular vesicles mesenchymal stem cells MICRORNA neurological disorders 
Epidural electrical stimulation for spinal cord injury
《中国神经再生研究:英文版》2021年第12期2367-2375,共9页Elliot H.Choi Sandra Gattas Nolan J.Brown John D.Hong Joshua N.Limbo Alvin Y.Chan Michael Y.Oh 
This work was supported by the Medical Scientist Training Program T32GM007250 and Predoctoral Training in Molecular Therapeutics Program T32GM008803(to EHC).
A long-standing goal of spinal cord injury research is to develop effective repair strategies,which can restore motor and sensory functions to near-normal levels.Recent advances in clinical management of spinal cord i...
关键词:central nervous system chondroitin sulfate proteoglycans epidural electrical stimulation glial scar GLIOSIS neural activity NEUROMODULATION OLIGODENDROCYTE spinal cord injury 
Lithium beyond psychiatric indications:the reincarnation of a new old drug
《中国神经再生研究:英文版》2021年第12期2383-2387,共5页Matteo Haupt Mathias Bähr Thorsten R.Doeppner 
Lithium has been used in the treatment of bipolar disorders for decades,but the exact mechanisms of action remain elusive to this day.Recent evidence suggests that lithium is critically involved in a variety of signal...
关键词:Alzheimer’s disease apoptosis bench-to-bedside translation inflammation ischemic stroke LITHIUM NEUROGENESIS neuroprotective agent Parkinson’s disease traumatic brain injury 
Abnormal metal homeostasis as a common drug target to combat neurodegenerative diseases
《中国神经再生研究:英文版》2021年第12期2388-2389,共2页Dagmar Pretsch 
The author is a recipient of a DOC Fellowship of the Austrian Academy of Sciences(Dr.Ignaz Seipel-Platz 2,1010 Vienna)at the Department of Pharmacognosy,University of Vienna,Althanstrasse 14,A-1090 Vienna,Austria.
As life expectancy increases,the prevalence of age-related diseases will also increase.There has been an estimation that 50 million individuals are living with dementia in 2019.This number will increase to 75 million ...
关键词:DISEASES HUNTINGTON DEGENERATIVE 
Caspase-1:an important player and possible target for repair of the blood-brain barrier underlying neurodegeneration
《中国神经再生研究:英文版》2021年第12期2390-2392,共3页Daniel Rand Itzik Cooper 
This work was supported by the Defense Threat Reduction Agency-Joint Science&Technology Office for Chemical&Biological Defense(No.11816372);the Nehemia Rubin Excellence in Biomedical Research-The TELEM Program supported by the Aaron Gutwirth Fund and by Ministry of Science and Technology(No.3-13576).
Our ageing population is bearing an increasing burden on society with an unprecedented rise in brain disease,especially neurodegeneration.Treatment for neurodegeneration is practically nonexistent,one major reason bei...
关键词:NEURODEGENERATION BARRIER REMOVE 
Microglia activation:a role for mitochondrial DNA?
《中国神经再生研究:英文版》2021年第12期2393-2394,共2页Marcello Pinti Diana Ferraro Milena Nasi 
The present work was supported by the Italian Multiple Sclerosis Foundation(FISM)[grant“Mitochondrial DAMPs in Multiple Sclerosis:a pilot study”,code 2017/R/10](to MN and DF).
Microglial cells and perivascular macrophages are the only resident immune cells of the brain parenchyma and act as innate immune sentinels in the central nervous system(CNS).Microglial cells are vital for the mainten...
关键词:HOMEOSTASIS ACTIVATION STRICT 
Light of the stars:calcium signals light up astrocytes in the presence of autoreactive CD4+T cells
《中国神经再生研究:英文版》2021年第12期2395-2396,共2页Jelena BogdanovićPristov Ljiljana Nikolić 
The present work was supported by the Ministry of Education,Science and Technological Development of Republic of Serbia(Contract No.451-03-68/2020-14/200007(to LN),451-03-68/2020-14/200053)(to JBP),and a Fellowship Start up for Science from the Centre for Leadership Development(to LN).
Introduction:Astrocytes play important roles in the central nervous system(CNS)to support and regulate CNS function.They are abundant type of glia that form a meshwork of interconnected cells almost completely tiling ...
关键词:function. ASTROCYTES cytes 
A pilot exploration with Posiphen to normalize amyloid precursor protein in Down syndrome
《中国神经再生研究:英文版》2021年第12期2420-2421,共2页Xu-Qiao Chen 
Down syndrome(DS)pathology:DS is the most common cause of Alzheimer’s disease(AD)and has a known AD-causing genetic variation which is trisomy of the whole or part of Homo sapiens chromosome 21(HSA21)(Chen and Mobley...
关键词:al. AMYLOID PATHOLOGY 
Multiple sclerosis:why we should focus on both sides of the(auto)antibody
《中国神经再生研究:英文版》2021年第12期2422-2424,共3页Jeroen den Dunnen Lynn Mes Willianne Hoepel Joost Smolders 
Various clinical and experimental findings suggest a pathogenic role of antibodies in multiple sclerosis(MS).Yet,whether antibodies contribute to the pathogenesis or progression of MS is still a subject of intense deb...
关键词:SCLEROSIS ANTIBODIES clinical 
Advance in the use of gold nanoparticles in the treatment of neurodegenerative diseases:new perspectives
《中国神经再生研究:英文版》2021年第12期2425-2426,共2页Gustavo de Bem Silveira Alexandre Pastoris Muller Ricardo Andrez Machado-de-Ávila Paulo Cesar Lock Silveira 
The present work was supported by CAPES-001(to PCLS).
Various conditions affecting nerve cells and the nervous system due to the loss of neurons and their connecting networks are described under the superordinate phrase“Neurodegenerative diseases”.Such diseases lead to...
关键词:DISEASES DEGENERATIVE TREATMENT 
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